Fairly rough notes so far,

pip install build

python -m build (will build both sdist and wheel)

In most cases you might be better building just the wheel, ie

python -m build --wheel

export ARCHFLAGS="-arch x86_64"
python -m build

alternatively / preferentially -arch aarch64

• Unpack wheel
• e.g.

diff -rq --exclude='*.pyc' --exclude='__pycache__' --exclude='*.so' --exclude='*.build' --exclude='.DS_Store' --exclude='*.h' --exclude='*.c' ./PYME ./dist/python_microscopy-25.6.5-cp313-cp313-macosx_10_16_x86_64/PYME

Obviously substituting the path to the un-packed wheel. It's a bit of a judgement call what should make it in (I exclude a bunch of the bitrot and super-experimental stuff by default), but if you've added something new and it doesn't make it through this should pick up on it.

Ensure build, meson and meson-python are installed alongside standard install dependencies

pip install --no-build-isolation --editable .  

To recompile extension modules:

pip install --no-deps --no-build-isolation --editable . 

replacing the build subdir (e.g. cp313) with the one appropriate for your python version (i.e. the one that was generated with pip install -e above)